Structure of PDB 3s43 Chain B

Receptor sequence
>3s43B (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPLVTIKIGGQLKEALLDTGADDTIIEEMSLPGRWKPKMVGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPINIIGRNLLTQIGATLNF
3D structure
PDB3s43 Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
ChainB
Resolution1.26 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D125 T126 G127
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 478 B D125 G127 A128 D130 V147 G149 I150 D25 G27 A28 D30 V47 G49 I50 PDBbind-CN: -logKd/Ki=8.60,Ki=2.53nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3s43, PDBe:3s43, PDBj:3s43
PDBsum3s43
PubMed22238126
UniProtQ7SSI0

[Back to BioLiP]