Structure of PDB 3s3r Chain B

Receptor sequence
>3s3rB (length=249) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
VEIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSVE
LSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYP
FPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNV
KNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRI
IGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN
3D structure
PDB3s3r Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
ChainB
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q94 C100 H270 N290
Catalytic site (residue number reindexed from 1) Q25 C31 H196 N216
Enzyme Commision number 3.4.22.1: cathepsin B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0IW B Q94 C100 W101 L139 E142 G143 G144 G269 H270 W292 E316 Q25 C31 W32 L65 E68 G69 G70 G195 H196 W218 E242
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3s3r, PDBe:3s3r, PDBj:3s3r
PDBsum3s3r
PubMed21832058
UniProtQ8MNY2

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