Structure of PDB 3s3k Chain B

Receptor sequence
>3s3kB (length=285) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MASRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCN
RPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQG
PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGD
IKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTL
VRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDI
FGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
3D structure
PDB3s3k Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D210 C242 R248 S249 Q286
Catalytic site (residue number reindexed from 1) D190 C222 R228 S229 Q266
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CSN B K154 C242 A244 V246 Q286 K134 C222 A224 V226 Q266 PDBbind-CN: -logKd/Ki=4.01,Kd=97.69uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3s3k, PDBe:3s3k, PDBj:3s3k
PDBsum3s3k
PubMed22007620
UniProtP35992|PTP10_DROME Tyrosine-protein phosphatase 10D (Gene Name=Ptp10D)

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