Structure of PDB 3s1a Chain B

Receptor sequence

>3s1aB (length=491) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

EHQAIAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNG
IIEFDEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPE
GQEVVGGFDLSALIERINYAIQKYRARRVSIDSVTSVFQQYDASSVVRRE
LFRLVARLKQIGATTVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEG
ERRRRTLEILKLRGTSHMKGEYPFTITDHGINIFPLGAMRLTQRSSNVRV
SSGVVRLDEMCGGGFFKDSIILATGATGTGKTLLVSRFVENACANKERAI
LFAYEESRAQLLRNAYSWGMDFEEMERQNLLKIVCAYPESAGLEDHLQII
KSEINDFKPARIAIDSLSALARGVSNNAFRQFVIGVTGYAKQEEITGLFT
NTSDQFMGAHSITDSHIEEITDTIILLQYVEIRGEMSRAINVFKMRGSWH
DKAIREFMISDKGPDIKDSFRNFERIISGSPTRITVDEKSE

3D structure

PDB

3s1a Combined SAXS/EM Based Models of the S. elongatus Post-Translational Circadian Oscillator and its Interactions with the Output His-Kinase SasA.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	B	K457 M458 R459 G460 S461 W462 H463	K444 M445 R446 G447 S448 W449 H450
BS02	ATP	B	K224 L225 R226 T228 S229 H230 K232	K211 L212 R213 T215 S216 H217 K219
BS03	ATP	B	G291 G293 K294 T295 L296 W331 R451 I472	G278 G280 K281 T282 L283 W318 R438 I459
BS04	ATP	B	G49 T50 G51 K52 T53 L54 S89 F90 I239	G36 T37 G38 K39 T40 L41 S76 F77 I226
BS05	MG	B	T290 T415	T277 T402
BS06	MG	B	K52 D145	K39 D132

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3s1a, PDBe:3s1a, PDBj:3s1a
PDBsum	3s1a
PubMed	21887298
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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