Structure of PDB 3rw9 Chain B

Receptor sequence
>3rw9B (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
AIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLV
LDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKH
PSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQ
DAFDVIITDSSGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLI
KEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLT
QQQVAQMQLKYYNSDVHRAAFVLPEFARKALN
3D structure
PDB3rw9 Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.
ChainB
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DSH B Q49 Q70 G101 G103 E124 I125 D155 G156 D173 S174 S175 P180 A181 L184 Q35 Q56 G87 G89 E110 I111 D141 G142 D159 S160 S161 P163 A164 L167 MOAD: Kd=1.1uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3rw9, PDBe:3rw9, PDBj:3rw9
PDBsum3rw9
PubMed21898642
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

[Back to BioLiP]