Structure of PDB 3rn8 Chain B

Receptor sequence
>3rn8B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKN
KWWYDKGEC
3D structure
PDB3rn8 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU B Y61 L90 T91 R96 G141 S142 T143 E193 Y59 L88 T89 R94 G139 S140 T141 E191
BS02 RN8 B P105 S108 S217 K218 G219 N242 P103 S106 S215 K216 G217 N240
BS03 ZN B H23 E30 H21 E28
BS04 ZN B E42 H46 E40 H44
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3rn8, PDBe:3rn8, PDBj:3rn8
PDBsum3rn8
PubMed21543522
UniProtP42262|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

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