Structure of PDB 3rn5 Chain B

Receptor sequence
>3rn5B (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
EGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTL
LKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKA
GETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGV
RNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAK
3D structure
PDB3rn5 Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K309 R311 K335 I337 K163 R165 K189 I191
BS02 dna B K204 E248 T249 K58 E102 T103
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0035458 cellular response to interferon-beta

View graph for
Biological Process
External links
PDB RCSB:3rn5, PDBe:3rn5, PDBj:3rn5
PDBsum3rn5
PubMed22483801
UniProtO14862|AIM2_HUMAN Interferon-inducible protein AIM2 (Gene Name=AIM2)

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