Structure of PDB 3re4 Chain B

Receptor sequence
>3re4B (length=249) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence]
DLKKIESYLDKLRIKEKDGEERKIYAEVLDGRTLKTLYKLSAKGYITAMG
GVISTGKEANVFYADGVFDGKPVAMAVKIYRIEDEYLYGDERFDMRRISP
KEKVFIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPT
LVELGRELKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDKVY
FIDMGQAVTLRHPMAESYLERDVRNIIRFFSKYGVKADFEEMLKEVKGE
3D structure
PDB3re4 Interaction of rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity.
ChainB
Resolution1.997 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TO1 B S56 A78 M147 F149 I150 P156 M203 I211 S54 A76 M138 F140 I141 P147 M194 I202 MOAD: Kd~40nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3re4, PDBe:3re4, PDBj:3re4
PDBsum3re4
PubMed22629386
UniProtO28471|RIO1_ARCFU RIO-type serine/threonine-protein kinase Rio1 (Gene Name=rio1)

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