Structure of PDB 3rc0 Chain B

Receptor sequence
>3rc0B (length=414) Species: 9606 (Homo sapiens) [Search protein sequence]
LDPVACFLSWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQAGELLFVV
PRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRP
YFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIV
LPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEPNSPVMVPAAD
ILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYG
FVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMV
GEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQSLTITNIPKLK
ASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRY
GQKMILHQLLELTS
3D structure
PDB3rc0 Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
ChainB
Resolution2.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S224 F225 Q226 Y285 Y297 S182 F183 Q184 Y237 Y249
BS02 SAM B A73 G74 Y75 A222 Y223 D248 I249 N251 H252 Y285 Y297 F299 A31 G32 Y33 A180 Y181 D200 I201 N203 H204 Y237 Y249 F251
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0051059 NF-kappaB binding
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0018022 peptidyl-lysine methylation
GO:0018026 peptidyl-lysine monomethylation
GO:0019827 stem cell population maintenance
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032259 methylation
GO:0048863 stem cell differentiation
GO:0050727 regulation of inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rc0, PDBe:3rc0, PDBj:3rc0
PDBsum3rc0
PubMed21515635
UniProtQ8TBK2|SETD6_HUMAN N-lysine methyltransferase SETD6 (Gene Name=SETD6)

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