Structure of PDB 3r75 Chain B

Receptor sequence

>3r75B (length=622)

RNLFDRVLHGQAPCFALIARSTGSAGERAMIDVFAGAVSYPSSLAELPLA
APTATGADRQELLVMVPYRQLHERGFKTHDDGAPLVAITCDEHETVSAQL
ALAAIPDADTALGERHFDIDDEAYAEIVERVITDEIGTGAGSNFVIKRTL
EGDLDDYSPAKALAVFKRLMRREVGAYWIFVIHTGERTFVGATPERHLTL
HEGCATMNPISGTYRYPQSGPTIDGINAFLGDRKESDELYMVLDEELKMM
ARICPAGGQVTGPHLREMARLAHTEYFIVGHTEADVRDLLRETMFAPTVT
GSPIESATRVIARHERAGRGYYSGIAALIGRDARGGRTLDSAILIRTAEI
DRAGHVRIGVGSTLVRHSDAVSEVMETHAKVAALSNAFDPPEAGPALGQH
PSVQAALRERNEGIADFWFRPYGGRAELSGCRALIVDAEDHFTAMIAQQL
SSLGLATEVCGVHDAVDLARYDVVVMGPGPGDPSDAGDPRIARLYAWLRH
LIDEGKPFMAVCLSHQILNAILGIPLVRREVPNQGIQVEIDLFGQRERVG
FYNTYVAQTVRDEMDVDGVGTVAISRDPRTGEVHALRGPTFSSMQFHAES
VLTVDGPRILGEAITHAIRREK

3D structure

• PDB: 3r75 Ligand Binding Induces an Ammonia Channel in 2-Amino-2-desoxyisochorismate (ADIC) Synthase PhzE.
• Chain: B
• Resolution: 2.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N149 E201 E244 H279 T304 Y328 R352 T369 E382 K386
• Catalytic site (residue number reindexed from 1): N143 E195 E238 H273 T298 Y322 R346 T363 E376 K380
• Enzyme Commision number: 4.1.3.27: anthranilate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	E244 E382	E238 E376
BS02	PYR	B	Y328 R352 V366 G367 K386	Y322 R346 V360 G361 K380
BS03	ZN	B	C526 Y566 H611	C512 Y552 H597

Gene Ontology

Molecular Function

• GO:0004049 anthranilate synthase activity
• GO:0016829 lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000162 tryptophan biosynthetic process
• GO:0006541 glutamine metabolic process
• GO:0009058 biosynthetic process

External links

• PDB: RCSB:3r75, PDBe:3r75, PDBj:3r75
• PDBsum: 3r75
• PubMed: 21454481
• UniProt: Q396C7