Structure of PDB 3r3l Chain B

Receptor sequence

>3r3lB (length=514)

KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKQ
RRDDSDLKRLRDLNQAVNNLVELKSTQQKSVLRVGTLSSDDLLTLAADLE
KLKSKVTRTERPLSSGVYMGNLSSQQLDQRRALLNLIGMDGVVRVWDVKN
AELLNNQFGTMPSLTLACLTKQGQVDLNDVVQALTDLGLIYTAKYPNTSD
LDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETI
KVSPQSMDGILKSILKVKRALGMFVSDTPGERNPYENILYKICLSGDGWP
YIASRTSIVGRAWENTVVDLGLTYSQLMTLKDAMLQLDPNAKTWMDIEGR
PEDPVEVALYQPISGCYIHFFREPTDLKQFKQDAKYSHGIDIADLFAAQP
GLTSAVIEALPRNMVITCQGSEDIKKLLESQGRKDIKLIDIALSKIDSRK
FENAVWDQYKDLCHMHTGVVVEKKKEEITPHCALMDCIMFDAAVSGGLNT
LVLRAVLPRDMVFR

3D structure

• PDB: 3r3l Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy.
• Chain: B
• Resolution: 2.449 Å

Enzymatic activity

• Enzyme Commision number: 3.1.13.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	B	D204 S225 H226	D186 S207 H208
BS02	MN	B	D389 E391 D533	D346 E348 D486
BS03	MN	B	R68 N173 Q175	R61 N155 Q157
BS04	ZN	B	E399 C506 H509 C529	E356 C463 H466 C482

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0019049 virus-mediated perturbation of host defense response
• GO:0039689 negative stranded viral RNA replication
• GO:0039696 RNA-templated viral transcription
• GO:0039724 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity

Cellular Component

• GO:0019013 viral nucleocapsid
• GO:0019029 helical viral capsid
• GO:0030430 host cell cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3r3l, PDBe:3r3l, PDBj:3r3l
• PDBsum: 3r3l
• PubMed: 21917929
• UniProt: Q9DQX7