Structure of PDB 3r2b Chain B

Receptor sequence
>3r2bB (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ
DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGEL
FSRIQDAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN
AILKLTDFGFAKETTPYYVAPEVLYDKSCDMWSLGVIMYILLCGYPPFYS
GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHP
WIMQSTKVPQTPLHTSRVLKED
3D structure
PDB3r2b Structure-based lead identification of ATP-competitive MK2 inhibitors.
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D136 K138 E140 N141 D157
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 05B B L72 V78 A91 K93 L141 D142 N191 L193 T206 D207 L26 V32 A45 K47 L95 D96 N141 L143 T156 D157 BindingDB: EC50=620nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3r2b, PDBe:3r2b, PDBj:3r2b
PDBsum3r2b
PubMed21565500
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

[Back to BioLiP]