Structure of PDB 3r0w Chain B

Receptor sequence

>3r0wB (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWQRPIVTIKIGGQLKEALLNTGADDTVLEEVNLPGRWKPKLIGGI
GGFVKVRQYDQVPIEICGHKVIGTVLVGPTPTNVIGRNLMTQIGCTLNF

3D structure

PDB

3r0w Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

Chain

Resolution

1.7 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	N25 T26 G27
Catalytic site (residue number reindexed from 1)	N25 T26 G27
Enzyme Commision number	3.1.26.13: retroviral ribonuclease H.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RSY	B	N25 G27 G48 P81 T82 V84	N25 G27 G48 P81 T82 V84	PDBbind-CN: -logKd/Ki=4.52,IC50=30.0uM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

External links