Structure of PDB 3qxm Chain B

Receptor sequence
>3qxmB (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
NRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYE
IRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDF
SKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI
STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRN
CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW
RGNGCP
3D structure
PDB3qxm Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
ChainB
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDZ B E409 Y457 P485 L486 A487 R492 V654 G657 A658 T659 M706 E707 T710 E11 Y59 P87 L88 A89 R94 V136 G139 A140 T141 M188 E189 T192 MOAD: Ki=33nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3qxm, PDBe:3qxm, PDBj:3qxm
PDBsum3qxm
PubMed21893069
UniProtQ13002|GRIK2_HUMAN Glutamate receptor ionotropic, kainate 2 (Gene Name=GRIK2)

[Back to BioLiP]