Structure of PDB 3qw4 Chain B

Receptor sequence

>3qw4B (length=445) Species: 5661 (Leishmania donovani)

TMSFFDLLNERAKRSLLCVGLDPRAKTAAAAVEECKRLIEQTHEYAAAYK
PNAAFFEFFGAEGWAALSEVIRAVPAGIPVVLDAKRGDIADTADAYATSA
FKHLNAHAITASPYMGSDSLQPFMRYPDKAVFVLCKTSNKGSNDLQCLRV
GDRYLYEAVAERAEGPWNVNGNVGLVVGATDPVALARVRARAPTLWFLVP
GIGAQGGSLKASLDAGLRADGSGMLINVSRGLARAADPRAAAKELCEEIN
AIRFAKGASVELAKALVDSHCVRFGNFTLKSGKSSPIYIDLRRLVTYPAI
MRLVAREYAKVLRHYKFDRIAGLPYAALPIASAISNEMNVPLIYPRREAA
IEGEYKKGDRVVIIDDLVSTETKVEAIEKLRSAGLEVVSIVVLVDRDMGA
KAFLNKLGYDFEAVVGLHQLLPLWRKSNAITSQQEADVRAFLGQW

3D structure

• PDB: 3qw4 The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization.
• Chain: B
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.23: orotidine-5'-phosphate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	U5P	B	D21 K49 N51 T136 S137 P199 Q204 S228 R229	D22 K50 N52 T137 S138 P200 Q205 S229 R230
BS02	U5P	B	D87 I88 T91	D88 I89 T92

Gene Ontology

Molecular Function

• GO:0004588 orotate phosphoribosyltransferase activity
• GO:0004590 orotidine-5'-phosphate decarboxylase activity
• GO:0016757 glycosyltransferase activity
• GO:0016831 carboxy-lyase activity

Biological Process

• GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
• GO:0006221 pyrimidine nucleotide biosynthetic process
• GO:0044205 'de novo' UMP biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3qw4, PDBe:3qw4, PDBj:3qw4
• PDBsum: 3qw4
• PubMed: 21507942
• UniProt: H9ABT8