Structure of PDB 3qv9 Chain B

Receptor sequence
>3qv9B (length=394) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
MSQLAHNVNLSIFEPISHHRANRIVCTIGPSTQSVEALKGLIRSGMSVAR
MNFSHGSHEYHQTTINNLRAAATELGAHIGLALDTKGPEILPAVSEKDRE
DLKFGVEQGIDMVFASFIRTAEQVQEVREALGEKGKDILIISKIENHQGV
QNIDGIIEASDGIMVARGDLGVEIPAEKVVVAQMILISKCNVAGKPVICA
TQMLESMTTNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQY
MARICLEAQSATNQAVMFNSIKKMQKLPMSPEEAVCSSAVNSVYEVRAKA
LLVLSNSGRSARLASKYRPDCPIICATTRMRTCRQLTITRSVDAVFYDAE
RYGEDENKEKRVQLGVDCAKKKGYVVPGDLMVVVHAQTRIIYVS
3D structure
PDB3qv9 The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R50 K239 T297
Catalytic site (residue number reindexed from 1) R50 K143 T201
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QV7 B N52 H55 G56 S57 Y60 H61 N52 H55 G56 S57 Y60 H61
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3qv9, PDBe:3qv9, PDBj:3qv9
PDBsum3qv9
PubMed21733839
UniProtQ4D9Z4

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