Structure of PDB 3qs1 Chain B

Receptor sequence
>3qs1B (length=327) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
AGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIG
CKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYK
FIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQ
AVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHF
GNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNN
PKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFIL
GDPFMRKYFTVFDYDNHTVGFALAKKK
3D structure
PDB3qs1 Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.
ChainB
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 N37 W39 Y75 D215 T218
Catalytic site (residue number reindexed from 1) D33 S36 N38 W40 Y76 D213 T216
Enzyme Commision number 3.4.23.38: plasmepsin I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 006 B D32 G34 N74 Y75 V76 S77 L128 D215 G217 T218 S219 I300 D33 G35 N75 Y76 V77 S78 L130 D213 G215 T216 S217 I299 PDBbind-CN: -logKd/Ki=7.96,Ki=11.0nM
BindingDB: IC50=280nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3qs1, PDBe:3qs1, PDBj:3qs1
PDBsum3qs1
PubMed21521654
UniProtP39898|PLM1_PLAFX Plasmepsin I (Gene Name=PMI)

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