Structure of PDB 3qgn Chain B

Receptor sequence
>3qgnB (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGPLPSVLQV
VNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMK
SPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
3D structure
PDB3qgn Crystallographic and kinetic evidence of allostery in a trypsin-like protease.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E190 G191 D192 S193 G194
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E23 M26 W29 D116 H119 P120 C122 Y134 K135 G136 R137 N159 M201 K202 R206 W207 E8 M11 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N152 M199 K200 R206 W207
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3qgn, PDBe:3qgn, PDBj:3qgn
PDBsum3qgn
PubMed21707111
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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