Structure of PDB 3qcm Chain B

Receptor sequence
>3qcmB (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
MEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPEN
KHKNRYINILAYDHSRVKLRPLPGSKHSDYINANYVDGYNKAKAYIATQG
PLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPTENTEEYGNI
IVTLKSTKIHACYTVRRFSIRNTKVKQNERVVIQYHYTQWPDMGVPEYAL
PVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTV
NVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKE
3D structure
PDB3qcm Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E955 D1028 C1060 R1066 T1067 Q1104
Catalytic site (residue number reindexed from 1) E129 D192 C224 R230 T231 Q268
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXW B Q845 I950 Y1023 W1026 V1031 P1032 V1038 F1041 R1066 T1069 Y1070 E1107 I1110 F1111 Q21 I124 Y187 W190 V195 P196 V202 F205 R230 T233 Y234 E271 I274 F275
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3qcm, PDBe:3qcm, PDBj:3qcm
PDBsum3qcm
PubMed21882820
UniProtP23470|PTPRG_HUMAN Receptor-type tyrosine-protein phosphatase gamma (Gene Name=PTPRG)

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