Structure of PDB 3qce Chain B

Receptor sequence
>3qceB (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
MEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPEN
KHKNRYINILAYDHSRVKLRPLPGKSKHSDYINANYVDGYNKAKAYIATQ
GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGN
IIVTLKSTKIHACYTVRRFSIRNTKNERVVIQYHYTQWPDMGVPEYALPV
LTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNV
LGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG
3D structure
PDB3qce Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E955 D1028 C1060 R1066 T1067 Q1104
Catalytic site (residue number reindexed from 1) E130 D190 C222 R228 T229 Q266
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXY B I950 Y1023 W1026 V1031 V1038 F1041 R1066 Y1070 Q1108 F1111 I125 Y185 W188 V193 V200 F203 R228 Y232 Q270 F273 MOAD: Ki=2.5uM
PDBbind-CN: -logKd/Ki=5.60,Ki=2.5uM
BindingDB: Ki=2500nM,IC50=2500nM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3qce, PDBe:3qce, PDBj:3qce
PDBsum3qce
PubMed21882820
UniProtP23470|PTPRG_HUMAN Receptor-type tyrosine-protein phosphatase gamma (Gene Name=PTPRG)

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