Structure of PDB 3q8s Chain B

Receptor sequence

>3q8sB (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]

SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLNYDVMTPMV
DILMKLFRNMVNVKMPFHLTLLSVCFCNLK

3D structure

PDB

3q8s Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine

Chain

Resolution

2.09 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	Q59 K60 E97 L99 R103 P299 Q300 S301 S303 E304 E305 S307	Q33 K34 E71 L73 R77 P273 Q274 S275 S277 E278 E279 S281
BS02	dna	B	E127 K207 P240 G241 G243 K245 T246 E358 S359 R360 Q361	E101 K181 P214 G215 G217 K219 T220 E327 S328 R329 Q330
BS03	MG	B	K237 I239 I242	K211 I213 I216
BS04	MG	B	D34 L35 D126	D8 L9 D100
BS05	TTP	B	L35 C37 F38 Y39 T65 Y68 R71 K77 D126	L9 C11 F12 Y13 T39 Y42 R45 K51 D100

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3q8s, PDBe:3q8s, PDBj:3q8s
PDBsum	3q8s
PubMed
UniProt	Q9UNA4\|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

[Back to BioLiP]