Structure of PDB 3q2h Chain B

Receptor sequence
>3q2hB (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLV
VVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAIL
FTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGH
VFNMPHDDAKQCASLNSHMMASMLNLDHSQPWSPCSAYMITSFLDNGHGE
CLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCTCSTLWCTGTLV
CQTKHFPWADGTSCGEGKWCINGKCVNKLVPR
3D structure
PDB3q2h The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
ChainB
Resolution2.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H149 H153 H159 H146 H150 H156
BS02 MG B H187 D278 N290 H178 D260 N272
BS03 QHF B T117 L118 G119 A121 F145 H149 E150 H153 H159 L182 T114 L115 G116 A118 F142 H146 E147 H150 H156 L174 MOAD: ic50=0.69nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3q2h, PDBe:3q2h, PDBj:3q2h
PDBsum3q2h
PubMed21300546
UniProtQ9UHI8|ATS1_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 1 (Gene Name=ADAMTS1)

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