Structure of PDB 3pz2 Chain B

Receptor sequence
>3pz2B (length=322) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QKDVTIKSDAPDTLLLEKHADYIASYGSEYCMSEYLRMSGVYWGLTVMDL
MGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYD
SIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKL
DAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQ
VNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWID
REKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPV
SPVFCMPEEVLQRVNVQPELVS
3D structure
PDB3pz2 Structure-Guided Development of Selective RabGGTase Inhibitors.
ChainB
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H190 R232 K235 D238 C240 Y241 D280 D287 H290
Catalytic site (residue number reindexed from 1) H181 R223 K226 D229 C231 Y232 D271 D278 H281
Enzyme Commision number 2.5.1.60: protein geranylgeranyltransferase type II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D238 C240 H290 D229 C231 H281
BS02 CA B H64 M66 H55 M57
BS03 3PZ B Y44 D238 W244 D287 F289 H290 Y35 D229 W235 D278 F280 H281 MOAD: ic50=724nM
PDBbind-CN: -logKd/Ki=6.14,IC50=724nM
BS04 GRG B R144 F147 H190 G192 Q193 C196 R232 K235 Y241 F293 R135 F138 H181 G183 Q184 C187 R223 K226 Y232 F284
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004659 prenyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008318 protein prenyltransferase activity
GO:0019840 isoprenoid binding
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005968 Rab-protein geranylgeranyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pz2, PDBe:3pz2, PDBj:3pz2
PDBsum3pz2
PubMed21520375
UniProtQ08603|PGTB2_RAT Geranylgeranyl transferase type-2 subunit beta (Gene Name=Rabggtb)

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