Structure of PDB 3pyy Chain B

Receptor sequence
>3pyyB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAV
VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGAKFPI
KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE
KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSIS
DEVEKEL
3D structure
PDB3pyy Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site.
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D382 A384 R386 N387 D400 P421
Catalytic site (residue number reindexed from 1) D125 A127 R129 N130 D143 P149
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STI B Y272 V275 K290 E305 M309 I332 T334 F336 M337 I379 H380 L389 A399 D400 F401 Y21 V24 K39 E48 M52 I75 T77 F79 M80 I122 H123 L132 A142 D143 F144 BindingDB: IC50=38nM,Kd=44nM,Ki=13nM,EC50=7e+1nM
BS02 3YY B A356 L359 L448 I451 A452 G482 C483 P484 A99 L102 L176 I179 A180 G210 C211 P212 BindingDB: IC50=398nM,EC50=794nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pyy, PDBe:3pyy, PDBj:3pyy
PDBsum3pyy
PubMed21338916
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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