Structure of PDB 3pxx Chain B

Receptor sequence
>3pxxB (length=274) Species: 243243 (Mycobacterium avium 104) [Search protein sequence]
MGRVQDKVVLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLA
TSRDLEEAGLEVEKTGRKAYTAEVDVRDRAAVSRELANAVAEFGKLDVVV
ANAGICPLGAHLPVQAFADAFDVDFVGVINTVHAALPYLTSGASIITTGS
VAGLIAAQGPGGAGYSYAKQLVDSYTLQLAAQLAPQSIRANVIHPTNVNT
DMLNSAPMYRQFRPDLEAPSRADALLAFPAMQAMPTPYVEASDISNAVCF
LASDESRYVTGLQFKVDAGAMLKF
3D structure
PDB3pxx Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S150 Y174 K178
Catalytic site (residue number reindexed from 1) S150 Y165 K169
Enzyme Commision number 1.1.1.275: (+)-trans-carveol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G13 R16 G17 Q18 D37 I38 L49 A50 V74 D75 V76 N102 A103 G104 I105 T148 Y174 K178 P204 N206 V207 T209 M211 G13 R16 G17 Q18 D37 I38 L49 A50 V74 D75 V76 N102 A103 G104 I105 T148 Y165 K169 P195 N197 V198 T200 M202
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0033702 (+)-trans-carveol dehydrogenase activity

View graph for
Molecular Function
External links
PDB RCSB:3pxx, PDBe:3pxx, PDBj:3pxx
PDBsum3pxx
PubMed28120876
UniProtA0A0H2ZV91

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