Structure of PDB 3pma Chain B

Receptor sequence
>3pmaB (length=238) Species: 9913 (Bos taurus) [Search protein sequence]
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTVDDLLVRIGKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPI
ELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRREQPSVLQVVNLPLV
ERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNR
WYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDR
3D structure
PDB3pma Interaction of thrombin with sucrose octasulfate.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D90 E184 G185 D186 S187 G188
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E23 V24 G25 L26 W29 D116 H119 P120 C122 F134 K135 R137 N159 K186D K202 N205 R206 W207 E8 V9 G10 L11 W14 D104 H107 P108 C110 F125 K126 R128 N146 K178 K194 N199 R200 W201
BS02 YYJ B D125 K126 F232 K235 D113 K114 F226 K229
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3pma, PDBe:3pma, PDBj:3pma
PDBsum3pma
PubMed21736375
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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