Structure of PDB 3pif Chain B

Receptor sequence

>3pifB (length=1056) Species: 28985 (Kluyveromyces lactis)

IPKFFHFISERWPQISQLIDGSQIPEFDNLYLDMNSILHNCTHGRLSEEE
VYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFRTAMDAE
KALQKAFDSNAITPGTEFMAKLTENLKYFIHDKITNDTRWQNVKVIFSGH
EVPGEGQHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLIILGLSTHDHHF
CLLREEVTTLETQNFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDD
FIFVLFTIGNDFLPNLPDLHLKKGAFPVLLQTFKEALQHMDGYINEQGKI
NLARFSIWLKYLSDFEYLNFEKKDIDVEWFNQQLENISLEGERKRTRMGK
KLLMKQQKKLIGAVKPWLLKTVQRKVTSDADFEIFPLEDKELVRANLDFL
KEFAFDLGLILAHSKSKDLYYFKLDLDSIAAAAAAAAAAAAAAAAAAAYS
ERFVEWKDQYYKDKDTDSLKEMTENYVGGLQWVLYYYYRGCPSWSWYYRY
HYAPRISDVIKGIDQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYFYP
NEVVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFIFNPQVDT
VYKTPLAGLFNDIEHNHCIEREFIPESMENVKFLFGLPKGAKLGASSLAG
FPSLKTLPLTAELAYNSSVVFNFPSKQQSMVLHIQDLYSLSDLAKRHMGK
IVYSRWPFLRESKLLSLITEETVYEGVKSGKLTKVIERKPQDFERKEFRE
LKMTLKSNYQRTKAILLDDISALAKVVPVNGLVRNSDGSYSKSFNETIEY
YPLQLIVEDVKNKDERYIEKEPLPINKEFPKGSKVVFLGDYAYGGEATVD
GYNSETRLKLTVKKGSLRAEPNIGKVRAKLDSQALRFYPTQAAAAAAAAA
AAAAAAAAVADWLSEARKPFVVVSLESDSLTKASMAAVESEIIKYVSLPD
SSEQKKLAKVPREAILNAESSYVLLRSQRFHLGDRVMYIQDSGKVPLHSK
GTVVGYTSIGKNVSIQVLFDNEIIAGNNFGGRLQTRRGLGLDSSFLLNLS
DRQLVY

3D structure

• PDB: 3pif Structural and biochemical studies of the 5' -> 3' exoribonuclease Xrn1.
• Chain: B
• Resolution: 2.92 Å

Enzymatic activity

• Enzyme Commision number: 3.1.13.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	B	Q178 D206 D208 D291	Q157 D185 D187 D261

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity
• GO:0008409 5'-3' exonuclease activity

Biological Process

• GO:0000956 nuclear-transcribed mRNA catabolic process

External links

• PDB: RCSB:3pif, PDBe:3pif, PDBj:3pif
• PDBsum: 3pif
• PubMed: 21297639
• UniProt: Q6CJ09