Structure of PDB 3pfv Chain B

Receptor sequence
>3pfvB (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
AADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLIL
SKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQD
RRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDK
TIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRL
FQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSC
TRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNP
DLTGLAENLY
3D structure
PDB3pfv Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
ChainB
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S70 P71 Y266 R286 C289 T290 R291 Q308 T309 I310 E326 Y329 S31 P32 Y227 R247 C250 T251 R252 Q269 T270 I271 E287 Y290
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3pfv, PDBe:3pfv, PDBj:3pfv
PDBsum3pfv
PubMed
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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