Structure of PDB 3peq Chain B

Receptor sequence
>3peqB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLKAFSKHIYNAYLKNFNMTKKKARSILTAPFVIHDIETLWQAEKGLVW
LPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKY
GVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEF
AVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFH
LQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQ
EIYKDMY
3D structure
PDB3peq Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3EQ B V281 F282 C285 T289 H323 L330 L339 V348 L353 I363 I364 K367 F368 H449 M453 L469 Y473 V61 F62 C65 T69 H103 L110 L119 V128 L133 I143 I144 K147 F148 H229 M233 L249 Y253 MOAD: ic50=31.6nM
BS02 JZR B L318 K319 E471 K474 L98 K99 E251 K254
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3peq, PDBe:3peq, PDBj:3peq
PDBsum3peq
PubMed21414782
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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