Structure of PDB 3p2e Chain B

Receptor sequence
>3p2eB (length=201) Species: 562 (Escherichia coli) [Search protein sequence]
LILKGTKTVDLSKDELTEIIGQFDRVHIDLGTGDGRNIYKLAINDQNTFY
IGIDPVKENLFDISKKIIKKPSKGGLSNVVFVIAAAESLPFELKNIADSI
SILFPWGTLLEYVIKPNRDILSNVADLAKKEAHFEFVTTYSDLSKAYFLS
EQYKAELSNSGFRIDDVKELDNEYVKQFNSLWAKRLAFGRKRSFFRVSGH
V
3D structure
PDB3p2e Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.
ChainB
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.180: 16S rRNA (adenine(1408)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B G32 T33 N38 D55 P56 A86 A87 E88 L104 F105 W107 T109 L110 S195 W197 G31 T32 N37 D54 P55 A85 A86 E87 L103 F104 W106 T108 L109 S180 W182 MOAD: Kd=0.6uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0046677 response to antibiotic

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3p2e, PDBe:3p2e, PDBj:3p2e
PDBsum3p2e
PubMed21062819
UniProtA8C927|NPMA_ECOLX 16S rRNA (adenine(1408)-N(1))-methyltransferase (Gene Name=npmA)

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