Structure of PDB 3oyp Chain B

Receptor sequence

>3oypB (length=175) Species: 11116 (Hepatitis C virus (isolate Japanese)) [Search protein sequence]

APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVDFIPVESM

3D structure

PDB

3oyp Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.

Chain

Resolution

2.76 Å

3D
structure

Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H57 D81 G137 S139
Enzyme Commision number	2.7.7.48: RNA-directed RNA polymerase. 3.4.21.98: hepacivirin. 3.4.22.- 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	T4 A5 Y6 S7 Q8 T10 R11 T19 S20 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65	T4 A5 Y6 S7 Q8 T10 R11 T19 S20 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65
BS02	peptide	B	H57 D81 K136 R155 A156 A157 C159	H57 D81 K136 R155 A156 A157 C159
BS03	ZN	B	Q41 F43 H57 L135 K136 G137 S139 F154	Q41 F43 H57 L135 K136 G137 S139 F154
BS04	ZN	B	C97 C99 C145	C97 C99 C145

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3oyp, PDBe:3oyp, PDBj:3oyp
PDBsum	3oyp
PubMed	21113170
UniProt	P26662\|POLG_HCVJA Genome polyprotein

[Back to BioLiP]