Structure of PDB 3oti Chain B

Receptor sequence

>3otiB (length=379) Species: 1877 (Micromonospora echinospora) [Search protein sequence]

RHMRVLFVSSPGIGHLFPLIQLAWGFRTAGHDVLIAVAEHADRAAAAGLE
VVDVAPDYSAVKVFEQVAKDNPRFAETVATRPAIDLEEWGVQIAAVNRPL
VDGTMALVDDYRPDLVVYEQGATVGLLAADRAGVPAVQRNQSAWRTRGMH
RSIASFLTDLMDKHQVSLPEPVATIESFPPSLLLEAEPEGWFMRWVPYGG
GAVLGDRLPPVPARPEVAITMGTIELQAFGIGAVEPIIAAAGEVDADFVL
ALGDLDISPLGTLPRNVRAVGWTPLHTLLRTCTAVVHHGGGGTVMTAIDA
GIPQLLAPDPRDQFQHTAREAVSRRGIGLVSTSDKVDADLLRRLIGDESL
RTAAREVREEMVALPTPAETVRRIVERIS

3D structure

PDB

3oti Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.

Chain

Resolution

1.597 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TYD	B	G10 G218 T219 G249 W268 T269 P270 L271 H284 G286 G288 T289	G14 G222 T223 G253 W272 T273 P274 L275 H288 G290 G292 T293
BS02	C0T	B	P7 G10 H11 F60 L82 V92 Q116 G117 Q137 S138 W140 G287 D308 F310 Q311	P11 G14 H15 F64 L86 V96 Q120 G121 Q141 S142 W144 G291 D312 F314 Q315

Gene Ontology

	Molecular Function
GO:0008194	UDP-glycosyltransferase activity
GO:0016758	hexosyltransferase activity
GO:0046527	glucosyltransferase activity

	Biological Process
GO:0017000	antibiotic biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3oti, PDBe:3oti, PDBj:3oti
PDBsum	3oti
PubMed	21987796
UniProt	Q8KND7

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