Structure of PDB 3os9 Chain B

Receptor sequence
>3os9B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMVVPSYDLLLEMLDA
3D structure
PDB3os9 Coupling of receptor conformation and ligand orientation determine graded activity.
ChainB
Resolution2.303 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KN1 B L346 T347 L41 T42 BindingDB: IC50=1300nM
BS02 KN1 B A350 D351 W383 L384 L525 A45 D46 W78 L79 L211 BindingDB: IC50=1300nM
External links
PDB RCSB:3os9, PDBe:3os9, PDBj:3os9
PDBsum3os9
PubMed20924370
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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