Structure of PDB 3ope Chain B

Receptor sequence
>3opeB (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
SYKKIRSNVYVDVKPLSCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRH
EWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQ
YHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYR
IGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGII
3D structure
PDB3ope Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y2169 Y2255
Catalytic site (residue number reindexed from 1) Y83 Y169
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C2220 C2268 C2275 C134 C182 C189
BS02 ZN B C2104 C2108 C18 C22
BS03 SAM B K2150 G2151 W2152 D2192 H2193 Y2194 R2214 F2215 N2217 H2218 Q2266 L2267 I2279 K64 G65 W66 D106 H107 Y108 R128 F129 N131 H132 Q180 L181 I193
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3ope, PDBe:3ope, PDBj:3ope
PDBsum3ope
PubMed21239497
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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