Structure of PDB 3op0 Chain B

Receptor sequence
>3op0B (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
RQWEEARALGRAVRMLQRLEEQCVDPRLSVSPPSLRDLLPRTAQLLREVA
HSRREAGGGGPGGPGGSGDFLLIYLANLEAKSRQVAALLPPRGRRSANDE
LFRAGSRLRRQLAKLAIIFSHMHAELHALFPGGKYCGHMYQLTKAPAHTF
WRESCGARCVLPWAEFESLLGTCHPVEPGCTALALRTTIDLTCSGHVSIF
EFDVFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQERLQACRDKPG
SYIFRPSCTRLGQWAIGYVSSDGSILQTIPANKPLSQVLLEGQKDGFYLY
PDGKTHNPDLTELGAENLYFQ
3D structure
PDB3op0 Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
ChainB
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S40 P41 Y244 R264 C267 T268 Y277 Q286 T287 I288 E300 G301 F306 S31 P32 Y235 R255 C258 T259 Y268 Q277 T278 I279 E291 G292 F297
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3op0, PDBe:3op0, PDBj:3op0
PDBsum3op0
PubMed
UniProtQ9ULV8|CBLC_HUMAN E3 ubiquitin-protein ligase CBL-C (Gene Name=CBLC)

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