Structure of PDB 3ols Chain B

Receptor sequence
>3olsB (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWA
KKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLD
RDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPL
VTAKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNK
GMEHLLNMKCKNVVPVYDLLLEML
3D structure
PDB3ols Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K314 L324 Q327 V328 E332 E493 K51 L61 Q64 V65 E69 E222
BS02 EST B L298 E305 M336 L339 L343 F356 I373 H475 L476 L35 E42 M73 L76 L80 F93 I110 H204 L205 BindingDB: IC50=1.1nM,Kd=0.5nM,EC50=2.1nM,Ki=0.015nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3ols, PDBe:3ols, PDBj:3ols
PDBsum3ols
PubMed20922740
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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