Structure of PDB 3ojy Chain B

Receptor sequence
>3ojyB (length=504) Species: 9606 (Homo sapiens) [Search protein sequence]
MPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDC
VTNRPCRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYK
KCQHEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTRF
RKPYNVESYTPQTQGKYEFILKEYESYSDFERNVTESGFSFGFKIPGIFE
LGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHY
EFLQRVKRLPLEYSYGEYRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAM
ERGDYTLNNVHACAKNDSVGKCRGILNEIKDRNKRDTMVEDLVVLVRGGA
SEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAY
SSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQG
LACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNSGPASE
TLDC
3D structure
PDB3ojy Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
ChainB
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B L84 N87 D89 D91 D97 E98 L78 N81 D83 D85 D91 E92
BS02 BMA B S15 W16 R31 S9 W10 R25
BS03 BMA B W19 R29 W13 R23
BS04 BMA B Q443 K444 S447 C496 W497 K508 Q416 K417 S420 C469 W470 K481
BS05 BMA B K444 W500 R506 K417 W473 R479
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ojy, PDBe:3ojy, PDBj:3ojy
PDBsum3ojy
PubMed21454577
UniProtP07358|CO8B_HUMAN Complement component C8 beta chain (Gene Name=C8B)

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