Structure of PDB 3ob1 Chain B

Receptor sequence
>3ob1B (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
MVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEG
KMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKL
SLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKS
FRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSL
LRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWA
IGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLT
3D structure
PDB3ob1 Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N79 S80 P81 D86 Y274 R294 C297 T298 Y307 Q316 T317 I318 F336 Y337 N25 S26 P27 D32 Y220 R240 C243 T244 Y253 Q262 T263 I264 F282 Y283
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3ob1, PDBe:3ob1, PDBj:3ob1
PDBsum3ob1
PubMed20877636
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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