Structure of PDB 3o37 Chain B

Receptor sequence
>3o37B (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLS
KPEVEYDCDAPNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQD
PVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNC
AEFNEPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB3o37 TRIM24 links a non-canonical histone signature to breast cancer.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N825 E826 D827 W828 Q833 N834 G835 L838 C840 C841 F860 P861 G863 N1 E2 D3 W4 Q9 N10 G11 L14 C16 C17 F36 P37 G39
BS02 ZN B C829 C832 H849 C852 C5 C8 H25 C28
BS03 ZN B C841 C844 C870 C17 C20 C46
External links
PDB RCSB:3o37, PDBe:3o37, PDBj:3o37
PDBsum3o37
PubMed21164480
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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