Structure of PDB 3o2m Chain B

Receptor sequence
>3o2mB (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK
LSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYI
VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENV
DIWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPAFMKKLQPTV
RNYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA
SKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELI
YKEVMDLE
3D structure
PDB3o2m Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N156 D169
Catalytic site (residue number reindexed from 1) N150 D163
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B M121 R127 Y130 S161 D162 C163 W324 E329 M115 R121 Y124 S155 D156 C157 W318 E323
BS02 46A B P184 T255 P178 T249
BS03 46A B F180 L198 G199 Y230 Q253 T255 V256 F174 L192 G193 Y224 Q247 T249 V250
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3o2m, PDBe:3o2m, PDBj:3o2m
PDBsum3o2m
PubMed21090814
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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