Structure of PDB 3nsq Chain B

Receptor sequence
>3nsqB (length=199) Species: 9606 (Homo sapiens) [Search protein sequence]
PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF
SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMD
KTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPG
RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
3D structure
PDB3nsq Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CHZ B F313 F346 F50 F83 PDBbind-CN: -logKd/Ki=5.21,Kd=6.2uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3nsq, PDBe:3nsq, PDBj:3nsq
PDBsum3nsq
PubMed21084305
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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