Structure of PDB 3ns7 Chain B

Receptor sequence
>3ns7B (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV
EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
3D structure
PDB3ns7 Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E74
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3NS B S339 W340 R341 R383 S23 W24 R25 R67 PDBbind-CN: -logKd/Ki=8.33,Ki=4.68nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ns7, PDBe:3ns7, PDBj:3ns7
PDBsum3ns7
PubMed20656488
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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