Structure of PDB 3nqw Chain B

Receptor sequence
>3nqwB (length=178) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
ATYPSAKFMECLQYAAFKHRQQRRKDPQETPYVNHVINVSTILSVEACIT
DEGVLMAALLHDVVEDTDASFEDVEKLFGPDVCGLVREVTDDKSLEKQER
KRLQIENAAKSSCRAKLIKLADKLDNLRDLQVNTPTGWTQERRDQYFVWA
KKVVDNLRGTNANLELKLDEIFRQRGLL
3D structure
PDB3nqw A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H36 H62 D63 D123 H35 H61 D62 D122
Gene Ontology
Molecular Function
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0015971 guanosine tetraphosphate catabolic process
GO:0042594 response to starvation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3nqw, PDBe:3nqw, PDBj:3nqw
PDBsum3nqw
PubMed20818390
UniProtQ9VAM9|MESH1_DROME Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Gene Name=Mesh1)

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