Structure of PDB 3nmx Chain B

Receptor sequence
>3nmxB (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHMLHLLEQIRAYCETCWEWQEAPMPAPVEHQICPAVCVLMKLSFDEEH
RHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGD
VANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKT
LREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGA
LAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL
QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIH
SKHKMIAMGSAAALRNLMANRPAKY
3D structure
PDB3nmx Structural basis for the recognition of Asef by adenomatous polyposis coli.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F458 M503 T506 N507 F510 G511 K516 Q542 S546 R549 N550 W553 W593 N594 F46 M91 T94 N95 F98 G99 K104 Q130 S134 R137 N138 W141 W181 N182
BS02 peptide B C451 K455 F458 C39 K43 F46
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nmx, PDBe:3nmx, PDBj:3nmx
PDBsum3nmx
PubMed21788986
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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