Structure of PDB 3njq Chain B

Receptor sequence
>3njqB (length=189) Species: 435895 (Human herpesvirus 8 type M) [Search protein sequence]
GLYVGGFVDVVSCPKLEQELYLDPDQVTDYLPVTEPLPITIEHLPETEVG
WTLGLFQVSHGIFCTGAITSPAFLELASRLADTSHVARAPVKNLPKEPLL
EILHTWLPGLSLSSIHPREPSGPVFQHVSLCALGRRRGTVAVYGHDAEWV
VSRFSSVSKSERAHILQHVSSCRLEDLSTPNFVSPLETL
3D structure
PDB3njq Enzyme inhibition by allosteric capture of an inactive conformation.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H46 S114 S116 H134 R142 R143
Catalytic site (residue number reindexed from 1) H43 S111 S113 H127 R135 R136
Enzyme Commision number 3.4.21.97: assemblin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NJQ B L79 L83 V89 A90 I105 L106 W109 S191 P192 L193 L76 L80 V86 A87 I102 L103 W106 S184 P185 L186 MOAD: Kd=1.7uM
PDBbind-CN: -logKd/Ki=4.89,Kd=13uM
BS02 NJQ B E45 L140 E42 L133 MOAD: Kd=1.7uM
PDBbind-CN: -logKd/Ki=4.89,Kd=13uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3njq, PDBe:3njq, PDBj:3njq
PDBsum3njq
PubMed21723875
UniProtP88911

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