Structure of PDB 3mxi Chain B

Receptor sequence
>3mxiB (length=211) Species: 10090 (Mus musculus) [Search protein sequence]
LPHGHMQTLIFLNLEATGLPSSRPEVTELCLLAVHRRALEGHPPPVPRPP
RVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAF
LQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKA
LESYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHA
RPFSTVKPMYG
3D structure
PDB3mxi X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants
ChainB
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E20 A21 L24 G80 T85 H124 N125 Y129 I156 S176 Y177 S178 L179 H195 E15 A16 L19 G69 T74 H113 N114 Y118 I145 S153 Y154 S155 L156 H172
BS02 CA B N18 E20 H195 D200 N13 E15 H172 D177
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3mxi, PDBe:3mxi, PDBj:3mxi
PDBsum3mxi
PubMed
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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