Structure of PDB 3mx6 Chain B

Receptor sequence
>3mx6B (length=260) Species: 782 (Rickettsia prowazekii) [Search protein sequence]
GSMIKIHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFI
TSHNAIPAPLNYKGFPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVI
LDGWYGDTSRMYYVGDVAIKPKRLIQVTYDAMMKGIEVVRPGAKLGDIGY
AIQSYAEKHNYSVVRDYTGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFF
TVEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGVTKDGFEIFTL
SPKKLDYPPY
3D structure
PDB3mx6 Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D94 D105 H168 H175 E201 E233
Catalytic site (residue number reindexed from 1) D96 D107 H170 H177 E203 E235
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET B F63 H77 D94 D105 H168 H175 E233 F65 H79 D96 D107 H170 H177 E235
BS02 MN B D105 H168 T199 E201 E233 D107 H170 T201 E203 E235
BS03 MN B D94 D105 E233 D96 D107 E235
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3mx6, PDBe:3mx6, PDBj:3mx6
PDBsum3mx6
PubMed28089350
UniProtQ9ZCD3|MAP1_RICPR Methionine aminopeptidase (Gene Name=map)

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