Structure of PDB 3mtf Chain B

Receptor sequence
>3mtfB (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
RTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETEL
YNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLD
TVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKR
VDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVD
QQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
3D structure
PDB3mtf A new class of small molecule inhibitor of BMP signaling.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3F B V214 A233 K235 L281 T283 Y285 H286 G289 D293 L343 D354 V13 A32 K34 L80 T82 Y84 H85 G88 D92 L142 D153 BindingDB: IC50=35nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mtf, PDBe:3mtf, PDBj:3mtf
PDBsum3mtf
PubMed23646137
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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