Structure of PDB 3ms9 Chain B

Receptor sequence
>3ms9B (length=272) Species: 10090 (Mus musculus) [Search protein sequence]
AMDPSSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL
TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY
LRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL
VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG
VLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW
QWNPSDRPSFAEIHQAFETMFQ
3D structure
PDB3ms9 Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D137 A139 R141 N142 D155 P176
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STI B L248 Y253 V256 A269 K271 E286 M290 I313 T315 F317 M318 I360 H361 L370 A380 D381 F382 L25 Y30 V33 A46 K48 E60 M64 I87 T89 F91 M92 I134 H135 L144 A154 D155 F156 BindingDB: IC50=10.8nM
BS02 MS9 B A337 L341 I432 A433 P465 A111 L115 I206 A207 P239
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ms9, PDBe:3ms9, PDBj:3ms9
PDBsum3ms9
PubMed20450175
UniProtP00520|ABL1_MOUSE Tyrosine-protein kinase ABL1 (Gene Name=Abl1)

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