Structure of PDB 3mp5 Chain B

Receptor sequence
>3mp5B (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
TLPKRVKIVEVGPMDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFV
SPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIF
GAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYE
GKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPL
AALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLA
TEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC
3D structure
PDB3mp5 Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.3.4: hydroxymethylglutaryl-CoA lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HMG B D42 Q45 S78 W81 F127 N138 N140 Y167 S169 T205 C266 D15 Q18 S51 W54 F100 N111 N113 Y140 S142 T178 C239
BS02 MG B D42 H233 H235 D15 H206 H208
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004419 hydroxymethylglutaryl-CoA lyase activity
GO:0005198 structural molecule activity
GO:0016829 lyase activity
GO:0016833 oxo-acid-lyase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006552 L-leucine catabolic process
GO:0006629 lipid metabolic process
GO:0007005 mitochondrion organization
GO:0046951 ketone body biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Cellular Component
External links
PDB RCSB:3mp5, PDBe:3mp5, PDBj:3mp5
PDBsum3mp5
PubMed20558737
UniProtP35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial (Gene Name=HMGCL)

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